Time to Decide? Dynamical Analysis Predicts Partial Tip/Stalk Patterning States Arise during Angiogenesis
Fig 5
Effect of Sirt1 on EC patterning speeds.
(A) Overview of the 2-cell model interaction with a positive regulation by Sirt1 (pink) and a negative regulation by Lfng (blue). (B) EC patterning speeds measured with different Sirt1 concentrations. Sirt1 = 1 c.u. optimal model, * and ** represent the threshold Sirt1 levels to transit from I:I āI:A/A:I and I:A/A:Iā A:A states respectively. State change in internal DLL values measured over time at (C) decreased Sirt1 (Sirt1 = 0.5 c.u.) and (D) increased Sirt1 (Sirt1 = 2 c.u.).