A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice
Fig 7
Effects of chronic treatment with compound-326 on PD markers and gene expression in WAT in DIO mice.
HFD-fed DIO mice were treated with compound-326 (10 mg/kg), p.o. for 6 weeks. Mice fed a normal diet (ND) were used as normal reference. (A) Levels of AA and DGLA in epididymal adipose tissue. (B) AA to DGLA ratio in epididymal adipose tissue. RT-qPCR was performed in epididymal (C) and subcutaneous fat tissues (D) after 6-week treatment. Data are expressed as mean ± SE (n = 8–9). *p≤ 0.05, **p≤ 0.01 vs. DIO vehicle by Aspin-Welch test. ¶p≤ 0.05, ¶¶p≤ 0.01 vs. DIO vehicle by Student's t-test.