A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice
Fig 5
Effects of chronic treatment with compound-326 on BW, calorie intake, and fat mass in DIO mice.
DIO mice were treated with 10 mg/kg compound-326, p.o., for 11 weeks. (A) Changes in BW. (B) Changes in daily calorie intake. (C) Weights of different body fat depots after 11-week treatment. Data are expressed as mean ± SE (n = 7). *p≤ 0.05, **p≤ 0.01 vs. DIO vehicle by Aspin-Welch test. ¶p≤ 0.05, ¶¶p≤ 0.01 vs. DIO vehicle by Student's t-test.