A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice
Fig 4
Effects of chronic treatment with compound-326 on plasma glucose and insulin during an OGTT, and HOMA-IR in DIO mice.
Oral glucose tolerance test (OGTT) was performed after chronic treatment with compound-326 for 6 weeks in DIO mice. (A) Changes in plasma glucose levels. (B) Effect on plasma glucose AUC. (C) Changes in plasma insulin levels. (D) Effect on HOMA-IR. Data are expressed as mean ± SE (n = 7). §p≤ 0.025 vs. DIO vehicle by Shirley-Williams test. ¶p≤ 0.05 vs. DIO vehicle by Student's t-test.