Deoxyarbutin Possesses a Potent Skin-Lightening Capacity with No Discernible Cytotoxicity against Melanosomes
Fig 4
Ultrastructural observation of melanosomes within keratinocytes of hyperpigmented guinea pig skin treated with HQ.
The dorsal skins of guinea pigs were treated as described for Fig 2. Marked vacuolations and fragmentations of melanosomes are seen in the depigmented skin after topical application of 5% HQ for 10 days (d1 and d2, arrows). The outer membranes of melanosomes in skins from (a) sham-irradiated control, (b) vehicle control, and (f) 10% D-Arb seem to be intact or have minor damage. Low-magnification views (a1-f1)are shown in the upper panels, the white boxes mark the areas magnified in the panels below (a2-f2). Scale bars: 2 μm(low-); 0.5 μm (high-magnification).