Deoxyarbutin Possesses a Potent Skin-Lightening Capacity with No Discernible Cytotoxicity against Melanosomes
Fig 2
Phenotypic changes and melanin distribution in hyperpigmented guinea pig skin treated with HQ.
A: Hyperpigmentation in guinea pig dorsal skin was induced by 308-nm MEL radiation. Changes in skin pigmentation were observed at the irradiated sites treated with (c) 3% H2O2, (d) 5% HQ, (e) 10% arbutin or (f) 10% D-Arb, once a day for 10 days, as described under Materials and methods. (a) Sham-irradiated control and (b) vehicle control. B: Fontana-Masson staining reveals supranuclear melanin as black-brown granules in the basal and suprabasal layers in skins of the vehicle control (b). Less pronounced melanin deposits are seen in (d) 5% HQ or (f) 10% D-Arb. It is noted that HQ caused an increase in epidermal thickness (d). Scale bar, 50 μm.