Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2
Fig 11
Overview of the three chemerin receptors.
Binding of chemerin to CMKLR1 leads to the activation of Gi/o proteins and arrestins as well as to calcium mobilization, Erk1/2 phosphorylation and internalization of the chemerin–receptor complex. Binding of chemerin to GPR1 leads mainly to the activation arrestins, although we cannot exclude contribution of G protein to GPR1 signaling. A weak calcium mobilization and Erk1/2 phosphorylation is also detected in response chemerin. GPR1 also internalizes efficiently in response to chemerin. In contrast, CCRL2 binds efficiently chemerin but does not signal nor internalize. The current hypotheses is that CCRL2 might present chemerin C-terminus (in red) to nearby cells expressing functional receptors or play the role of chemerin scavenger.