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Manufacturing of a Secretoneurin Drug Delivery System with Self-Assembled Protamine Nanoparticles by Titration

Fig 5

AFM images of secretoneurin loaded proticles.

Images recorded by atomic force microscopy showed spherical secretoneurin loaded proticles for mass ratio of 1 : 1 : 1.5 prepared by titration process (A) as well as by single protamine addition (B). Triangular clustered proticles were recorded for mass ratio 1 : 0.25 : 1.5 prepared by protamine addition at once (C).

Fig 5

doi: https://doi.org/10.1371/journal.pone.0164149.g005