G Protein-Coupled Receptor 43 Modulates Neutrophil Recruitment during Acute Inflammation
Fig 5
Acetate reduces neutrophil migration via a mechanism mediated by GPR43.
The total number of leukocytes in the peritoneal cavity was quantified in wildtype and Gpr43−/−mice at 24 h following sham or cecal ligation and puncture (CLP; (A)), or at 2 h after saline, fMLP or fMLP + acetate (B). The peritoneal neutrophil numbers of acetate-treated wildtype and Gpr43−/−mice at 2 h after saline or fMLP treatment were also measured (C). N ≥ 3 mice per group, **p < 0.01, *p < 0.05 vs corresponding Sham or Saline group, t test. ##p < 0.01, #p < 0.05 vs treated Wildtype, t test. &p < 0.05 vs fMLP-treated Wildtype, t test. N.S denotes not statistically significant vs fMLP-treated Gpr43−/−.