Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases
Fig 2
Interaction of dietary flavones with calf thymus (CT) DNA.
(A) UV-Vis spectra of CT-DNA, with 5-aza-2’deoxycytidine, (B) Apigenin, (C) Chrysin, and (D) Luteolin. UV-Vis spectra of CT-DNA with flavones were performed in 0.1 M phosphate buffer solution, with pH 7.4. 0.25 μM DNA solutions were prepared with flavones at 0.5 mM concentration. Absorption spectra of the solutions were recorded from 230 nm to 500 nm using Nanodrop. The experiment was repeated three times with similar results. Details are described in the Materials and Methods section.