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Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy

Fig 4

Proposed Fragmentation Scheme and Mass Spectrum for FTY720-Mitoxy and its Metabolites.

Mass spectrometry of FTY720-Mitoxy and metabolites detected [M+] molecular ions. Blue text and arrows indicate losses of H2O from [M]+. The ion with a hydroxyl group is shown in red. Ions including a carboxylic acid are shown in green.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0162162.g004