Amlexanox Blocks the Interaction between S100A4 and Epidermal Growth Factor and Inhibits Cell Proliferation
Fig 1
Interactions of EGF with mS100A4 monitored using fluorescence spectroscopy.
(A) Fluorescence emission spectra of EGF illustrating the changes in the intrinsic tryptophan fluorescence that occur with increasing concentrations of mS100A4 in the micromolar range. (B) Changes in the fluorescence intensities measured at 345 nm as a function of the mS100A4 concentration were calculated according to Eq 1. The binding was fitted (solid red line) to a one-site binding model.