Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics
Fig 4
The detailed tubulin-vinblastine interactions at the vinca site.
Vinblastine is in violetpurple stick representation. β1- and α2-tubulin are displayed as light and dark grey ribbons, respectively. Key residues forming the interaction with the ligand are in stick representation and are labeled. Hydrogen bonds are highlighted as dashed black lines, water molecules as red spheres.