AP-1 Inhibition by SR 11302 Protects Human Hepatoma HepG2 Cells from Bile Acid-Induced Cytotoxicity by Restoring the NOS-3 Expression
Fig 2
Transcription factors cJun and cFos bind to the NOS-3 promoter after GCDCA administration.
(A) Gene expression of GAPDH and NOS-3 as positive controls. (B) Enrichment of cJun and cFos binding to the NOS-3 promoter (position -666) after GCDCA administration. (C) Evaluation of the binding of GATA-1 and GATA-4 to the NOS-3 promoter (position -235) after GCDCA administration. Data expressed as mean ± SE of three independents experiments. Statistically significant difference versus control group (no GCDCA) is marked*.