Allostimulatory Effects of Dendritic Cells with Characteristic Features of a Regulatory Phenotype
Fig 3
LiClPAM3 DC pre-treatment results in accelerated allograft rejection in a fully MHC mismatched heterotopic heart transplant model.
Balb/c recipient mice were intravenously infused with 106 C57Bl/6N donor-derived DC or syngeneic DC seven days prior to transplantation. Graft survival was daily assessed by transabdominal palpation of the donor heart. LiClPAM3 DC pre-treatment (n = 9) resulted in accelerated allograft rejection compared to control DC pretreated mice (n = 10) (**p<0.01).