Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy
Fig 6
PTHrP(1ā36) significantly enhances beta cell mass at 90 days in PPx mice.
Histomorphometric analysis of pancreata in sham-veh (black bars) mice treated for 7 (D7) and 90 days (D90), and PPx-veh (grey bars) and PPx-PTHrP (P36) (horizontally-stippled bars) mice treated for 7 (D7, n = 5 mice/group), 30 (D30, n = 4 mice/group), and 90 (D90, n = 6 mice/group) days, measuring (A) pancreatic weight, (B) ratio of beta cell area/pancreatic area, and (C) beta cell mass. Significance of * p<0.05 versus sham-veh mice at D7, # p<0.05 versus sham-veh mice at D90, and ^ pā¤0.05 versus PPx-PTHrP mice at D90, by ANOVA.