Effects of Subretinal Gene Transfer at Different Time Points in a Mouse Model of Retinal Degeneration
Fig 7
M-cone and S-cone ERGs from rd11 mice following AAV8 (Y733F) vector treatments on different postnatal days.
(A) Photopic ERGs in rd11 eyes, 4 months after treatments at P10, 14, 18, or 22. M-cone ERGs were recorded at a green light intensity of 0.75 cd∙s/m2 while S-cone ERGs were recorded at a UV light intensity of 3.00 mW∙s/m2. M-cone (B) and S-cone ERG amplitudes (C) were compared between age-matched wild-type C57BL/6J, P10 to P22 treated, and untreated rd11 eyes (n = 8 mice). Age-matched wild-type C57BL/6J and untreated rd11 mice were used as controls. P, postnatal day; Inj, injected; M, months. **indicates P < 0.01, ***indicates P < 0.001, NS = no statistical difference.