D-TRP(8)-γMSH Prevents the Effects of Endotoxin in Rat Skeletal Muscle Cells through TNFα/NF-KB Signalling Pathway
Fig 1
Effect of D-Trp(8)-γMSH (γMSH) treatment (500 μg/kg i.p.) on: body weight gain (A), food intake (B), serum nitrite + nitrate levels (C), liver COX-2 mRNA (D) and liver TNFα mRNA (E) in control rats or in rats treated with LPS (250 μg/kg i.p.). PF = pair-fed rats. D-Trp(8)-γMSH treatment decreased the inhibitory effect of LPS administration on body weight and food intake as well as the stimulatory effect of LPS on serum concentration of nitrites + nitrates, liver TNFα and COX-2 mRNA (P<0.01). Results are expressed as means ± SE for 8–10 rats per group. *P< 0.05 and **P< 0.01, vs. their respective control group. ++P<0.01 vs. LPS-saline, °P<0.05, °°P<0.01 vs. PF. LSD multiple comparison test, following one-way ANOVA.