Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents
Fig 10
The representative aminothiazole 20 possesses bactericidal activity.
M. tuberculosis was inoculated to a starting of OD590 of 0.1 in medium containing compound 20. CFU/mL was enumerated at indicated time points by serial dilution onto solid medium. The limit of detection was 20. Note that the lines for 0.625, 1.25 and 2.5 overlap.