Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents
Fig 8
SAR at C-4 position of thiazole core.
aMIC (μM) is the minimum concentration required to inhibit the growth of M. tuberculosis in liquid culture. MICs of active compounds are the average of two independent experiments. bToxic concentration (TC50, in μM) is the concentration required to inhibit growth of Vero cells by 50%. Selectivity index (SI) is the ratio of TC50 to MIC. Cpd = compound; Rif = rifampicin; ND = not determined.