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Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents

Fig 4

Chemical synthesis of analogs comprised of thiazole core replacement.

Reagents:: (i) 4-(t-butyl)PhCOCl, EtOH, 1 h; (ii) EtOH, reflux, 16 h; (iii) H2SO4, r.t., 16 h; (iv) EDC, CH2Cl2, r.t., 16 h.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0155209.g004