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Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents

Fig 3

Chemical synthesis of C-4 ketone and carboxamide analogs.

Reagents: (i) EDC.HCl, HOBt, NCH3(OCH3), DIPEA, CH2Cl2, 16 h; (ii) CH3MgBr, THF, -78°C–r.t., 2 h; (iii) 1-adamantanoyl chloride, Et3N, THF, r.t., 1 h.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0155209.g003