Comparing the Effects of Isoflurane and Alpha Chloralose upon Mouse Physiology
Fig 2
Heart Rate drops under alpha chloralose sedation.
Mice retain a steady heart rate under isoflurane anesthesia, ranging from 463±20 beats/min to 489±20 beats/min. However, under alpha chloralose sedation, heart rate rapidly drops to below 350 beats/min, leading to a significant difference in heart rate between the treatment groups (F(1,384) = 516.2,p<0.0001, n = 9–23 per time point). The shaded region indicates the normal heart rate for an awake mouse at rest (450–500 beats/min).