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Discriminating Intercalative Effects of Threading Intercalator Nogalamycin, from Classical Intercalator Daunomycin, Using Single Molecule Atomic Force Spectroscopy

Fig 3

AFM topographs of DNA-daunomycin complex after incubation for (A) 1 h, (B) 18 h, (C) 36 h and (D) 48 h.

DNA_conc: 1.7 μg.ml^-1. Scale bar: 100 nm. Z-ranges: (A) 0–1.2 nm, (B) 0–0.9 nm, (C) 0–0.8 nm and (D) 0–1.2 nm.

doi: https://doi.org/10.1371/journal.pone.0154666.g003