GPR142 Agonists Stimulate Glucose-Dependent Insulin Secretion via Gq-Dependent Signaling
Fig 8
Proposed model of GPR142 mediated signaling pathways in β cells.
Stimulation of GPR142 triggers activation of Gq signaling and IP-3 formation, which is critical for enhancement of glucose-dependent insulin secretion. Activation of GPR142 can also result in the activation of Gi and suppression of cAMP, the contribution of which to GPR142 function remains to be determined. Activation of both Gq and Gi signaling by GPR142 agonism result in the phosphorylation of ERK, which may contribute to the previously reported beneficial effects on β cell survival and/or proliferation for GPR142 agonists [17].