Interleukin-1β-Targeted Vaccine Improves Glucose Control and β-Cell Function in a Diabetic KK-Ay Mouse Model
Fig 3
IL-1β targeted vaccine (1βEPP) improves insulin secretion and insulin sensitivity in KK-Ay mice.
(A) KK-Ay mice were fasted for 5 h before ipITT was performed. Blood glucose levels were measured at 0, 30, 60, 90 and 120 min after i.p. injection of insulin (0.75 U/kg body weight). (B) AUC for blood glucose (0–120 min) was calculated during the ipITT. Data are shown as mean ± SEM (n = 8). Compared with the KK-Ay control mice, *p < 0.05.