Interleukin-1β-Targeted Vaccine Improves Glucose Control and β-Cell Function in a Diabetic KK-Ay Mouse Model
Fig 2
IL-1β targeted vaccine (1βEPP) improves glucose tolerance in KK-Ay mice.
(A) 1βEPP -treated KK-Ay mice were challenged with 2 g/kg body weight of glucose, and then blood glucose levels were measured at 0, 30, 60, 90, 120 and 150 min. (B) Area under the curve (AUC) for blood glucose (0–150 min) during the ipGTT was calculated. (C) Serum insulin was measured during the ipGTT at 0 and 30 min after glucose injection. (D) Insulin stimulatory index as a ratio of stimulated (30 min) over basal (0 min) serum insulin concentration. (E) HOMA-IR as a product of fasting insulin and blood glucose levels. Data are shown as mean ± SEM (n = 8). Compared with the KK-Ay control mice, *p < 0.05, **p < 0.01.