Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis
Fig 5
Anti-inflammatory effects of PGE2 on adipose tissue.
(A) mRNA expression for COX-2, IL-6 and MCP-1 in human obese fat pads incubated with vehicle (Veh) or PGE2 (1 μM). (B) COX-2, IL-6 and MCP-1 expression in differentiated 3T3-L1 adipocytes growing in the presence of LPS (100 ng/ml) and incubated with increasing concentrations of PGE2 (0, 1 and 5 μM). The results are expressed as mean ± SEM. #, P<0.05, ##, P<0.01 and ###, P<0.001 for LPS versus untreated cells. *, P<0.05 and **, P<0.01 versus Veh or LPS.