Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis
Fig 2
High-throughput transcriptomic analysis of adipose tissue from control and obese individuals.
(A) Differential gene expression by Affymetrix Human Genome U219 expression arrays in omental adipose tissue from non-obese control individuals (n = 4) and obese patients (n = 4). The results are expressed as a matrix view of gene expression data (heat map) in which rows represent genes and columns represent hybridized samples. The intensity of each colour denotes the standardized ratio between each value and the average expression of each gene across all samples. Red pixels correspond to an increased abundance of mRNA in the samples indicated, whereas green pixels indicate decreased mRNA levels. (B) Integrative IPA of transcriptomic data. Genes significantly down-regulated are indicated in green; those that were significantly up-regulated are indicated in red. (C) Cascade of top regulators of inflammation and fibrosis detected by IPA software.