High Resolution Ultrasound and Photoacoustic Imaging of Orthotopic Lung Cancer in Mice: New Perspectives for Onco-Pharmacology
Fig 5
Contrast enhanced ultrasound imaging and Photoacoustic imaging of hypoxia on orthotopic lung tumors in mice.
(A) B-mode image of a lung tumor with corresponding contrast image before IV injection of Vevo MicroMarker™. Maximum Intensity Projection after injection of MicroMarker™. (B) B-mode image of a hypoxic lung tumor with corresponding OxyHemo photoacoustic images. With the OxyHemo-Mode, red areas indicate well oxygenated parts of the tumor whereas blue and dark areas indicate the presence of hypoxia. Regarding the 3D volumes, the red grid corresponds to the hypoxic region of tumor and green grid corresponds to the entire tumor. (C) B-mode image of a well oxygenated lung tumor with corresponding OxyHemo photoacoustic images showing absence of any hypoxic core.