A Novel Peptide for Simultaneously Enhanced Treatment of Head and Neck Cancer and Mitigation of Oral Mucositis
Fig 5
Mean daily mucositis scores in irradiated mice.
Irradiation of the tongue and oral mucosa was followed by daily treatment with AMP peptide or vehicle (PBS). Ulcerative oral mucositis that developed was scored as described in Methods. A mucositis score of 3.0 (broken line) indicates mucosal ulceration that correlates with significant human oral mucositis. Animals treated with the vehicle reached a score of 3 on Day 12, whereas mice treated with AMP peptide did not. Mucositis score was significantly lower on Days 11 (* P = 0.003) and 12 (** P = 0.03), but not Day 13 (P = 0.1) in animals treated with AMP peptide compared to those given the vehicle. Values are means ± SE.