Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme
Fig 2
Comparative Structural Features in the Catalytic Domains of SIRT5 and SIRT1.
(A) The superimposition (ribbon diagrams) of the catalytic domains of human SIRT5 (blue) and SIRT1 (tan). (B) A close view at the active site pockets of SIRT5 and SIRT1. The side chains of Y102 and R105I (yellow) in SIRT5 and of A313 and I316 (pink) in SIRT1 are presented as ball-and-stick models.