Adiponectin at Physiologically Relevant Concentrations Enhances the Vasorelaxative Effect of Acetylcholine via Cav-1/AdipoR-1 Signaling
Fig 2
Knockout of adiponectin receptor 1 (AdipoR1), but not receptor 2 (AdipoR2), abolishes APN-enhanced ACh-induced vasorelaxation.
(A) Enhanced vasorelaxation to ACh by APN (5μg/ml) was significantly decreased in AdipoR1-KO mouse aorta. (B) Enhanced vasorelaxation to ACh by APN (5μg/ml) was not affected in AdipoR2-KO mouse aorta. n = 5–7 mice/group. #, P<0.05; ##, P<0.01.