Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine
Fig 7
An inverse correlation between BBM-to-lumen cholesterol efflux and fractional lumen-to-circulation transit.
A, Comparison of fractional cholesterol transit (Fig 4C) and cholesterol efflux efficiency (Fig 2C) in ezetimibe-treated C57BL/6J mice. B, Comparison of fractional cholesterol transit and cholesterol efflux efficiency between WT and ABCG5/G8 DKO mice presented in Fig 5A, lower, and 5B. A and B, The mean relative efflux efficiency (%) and the median relative absorption (%) versus vehicle are plotted. Bars for the X-axis and Y-axis indicate the SEM and 50% coefficient interval, respectively.