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Dynamic Drusen Remodelling in Participants of the Nutritional AMD Treatment-2 (NAT-2) Randomized Trial

Fig 5

Drusen regression and its correlation with new geographic atrophy (GA).

A: Color photo, right eye, Visit 1 (V1). B: V1 photo with soft drusen segmented in green, total pixel area 2,452. GA is not present. C: Color photo, right eye, Visit 5 (V5), showing new GA, D: V5 photo with GAs segmented in blue, total pixel area 4,161. Drusen from V1 that were absorbed in the GA are overlaid and segmented in red, total pixel area 381, or 9% of geographic atrophy total area. Compared to the original drusen area present in V1 of 2,452 pixels, the 381 drusen pixels converting to GA in V5 represent 16% of the original drusen area.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0149219.g005