Inter-Protein Sequence Co-Evolution Predicts Known Physical Interactions in Bacterial Ribosomes and the Trp Operon
Fig 5
The plots illustrate the performance in predicting protein interaction partners. The left panels show the fraction of true positives among the first n PPI predictions, with n being the number indicated on the horizontal axis (solid lines). The dashed lines show the best possible (upper dashed line) and the mean of a random prediction (lower dashed line). The right panels show ROC-curves, which indicate the dependence of the true-positive predictions (TP/P) from the false positive predictions (FP/N). The area under the curve (AUC) is a global global measure for the prediction quality; it is 1/2 for a random, and 1 for a perfect prediction. A protein pair is identified as an interacting (true positive) pair, if at least one PDB structure with at least one inter-protein contacts exists.