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Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines

Fig 2

Synthesis of the Hydroxy Pyrazolines as CFTR potentiators.

(i) KOH, EtOH, stir; (ii) Chloro(methoxy)methane (MOMCl), K2CO3, Acetone, reflux; (iii) substituted benzaldehydes 2a-2c, KOH, EtOH, stir; (iv) 3N HCl, reflux; (v) 4-hydrazinobenzenesulfonamide hydrochloride (see Materials and Methods).

Fig 2

doi: https://doi.org/10.1371/journal.pone.0149131.g002