Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis
Fig 1
PGAM5 protects hearts (A-C) and brain (D-F) from ischemia-reperfusion (I/R) injury induced cell death.
I/R-induced myocardial damage was evaluated based on RPP values (A) and heart infarct size (B,C). Pgam5 WT mice n = 9, KO mice n = 10. (p <0.01 by Student t-test; Pgam5 KO mice exhibit increased infarct volumes (D, E). p<0.01 by Student t-test. Pgam5 WT mice n = 13, KO mice n = 16 after I/R induced brain damage and (F) greater neurological deficit scores. p<0.05 by Student t-test.