Iodixanol Has a Favourable Fibrinolytic Profile Compared to Iohexol in Cardiac Patients Undergoing Elective Angiography: A Double-Blind, Randomized, Parallel Group Study
Fig 5
(A) In vitro oxygen-centred free radical generation in samples of CA at 37°C. Iohexol generates free radicals at a significantly higher rate than iodixanol (n = 4; P<0.001). (B) Representative EPR spectra obtained for iodixanol alone, iodixanol + vitamin C (200 μM) and iohexol after 60 min incubation (37°C) with the oxygen-centred radical spin trap, tempone-H (1 mM). The characteristic 3-line spectrum is representative of formation of the stable radical adduct, 4-oxo-tempone, via reaction with oxygen-centred radicals; the amplitude of the signal is proportional to the amount of 4-oxo-tempone present.