Mother-Specific Signature in the Maternal Transcriptome Composition of Mature, Unfertilized Zebrafish Eggs
Fig 5
Characteristics of mother-specific maternal gene expression.
Characteristics of the 17 mother-specific gene clusters defined by relative gene-expression differences (see Fig 3A). (A) Clusterogram of chromosome location of the genes per cluster. Indicated is the relative occurrence of genes on a chromosome: dark blue, low; bright yellow, high. (B) Schematic representation of the overrepresented, TRANSFAC-defined transcription-factor binding sites (TFBS) in the upstream regions of the genes per cluster. Each horizontal line denotes a specific TFBS (specified in the same order from top to bottom in S13 File). A bar indicates that a specific TFBS is found overrepresented in the specified mother-specific gene cluster. Red bars indicate that a specific TFBS is found overrepresented in both related, inversed gene clusters. (C) Representation of the overrepresented miRNA target sequences in the transcript sequences of the genes per cluster, as well as for the expressed and non-expressed genes. The targets for miRNAs reported in the following references were tested: a Abramov et al. [51], b: Juanchich et al. [52], c: Yao et al. [53], d: Wei et al. [54], b* whereas in [52] the minor form of miR-181 was reported, here the targets for the major form of miR-181 were tested, because in TargetScanFish 6.2 no targets for miR-181* are available.