Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice
Fig 5
CBPΔCH1/ΔCH1 mice showed increased hippocampal long-term potentiation (LTP).
(A-C) Mean field excitatory postsynaptic potentials (fEPSPs) as a function of stimulation intensity (A), paired-pulse ratios as a function of interstimulus interval (B), and mean fEPSPs as a function of time before and after 200-Hz tetanus (applied at time 0) (C) measured at CA3-CA1 synapses in 2–3 slices per animal from WT (N = 4) and CBPΔCH1/ΔCH1 (N = 5) mice. * p<0.05.