Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington’s Disease
Fig 4
Summary plots of the peptidome of Q7Q7 cells in response to proteasome inhibitors.
A: Cells were treated with 200 nM epoxomicin for 1 hour. B: Cells were treated with 500 nM bortezomib for 1 hour. The relative levels of all peptides identified by MS/MS analysis in each of the inhibitor-treated replicates was compared to the average level of the peptide in the untreated control replicates. The y-axis represents the relative peptide levels (log-scale) and the x-axis represents the rank order of peptides sorted according to the relative level. If the ratio was <0.20 or >5.0, the value was capped at 0.20 or 5.0 to reflect the typical signal to noise ratio. Red circles indicate the ratio of each replicate of identified peptides in inhibitor-treated cells, expressed relative to the average control value. Black circles indicate the ratio of each control replicate expressed relative to the average control value.