KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism
Fig 4
Baseline metabolic differences between SW48 KRAS WT and G13D mutant tumors.
A-C: Glutathione metabolism pathways (A), glycogen metabolism (B) and relative expression of pathway metabolites in KRAS WT vs KRAS mutant tumors treated with vehicle for 1 and 8 hrs. The numbers indicate the fold change of each metabolite in KRAS mutant tumors compared to KRAS WT tumors and are the average of metabolite levels from 5 different tumors. C: Relative expression of free long chain fatty acids, acetyl coA, acetylcarnitine and citrate in KRAS mutant vs KRAS WT tumors. Green boxes indicates a ratio <1, with dark green boxes as highly significant (p ≤0.05) and light green boxes as less significant (0.05<p<0.1). Red boxes indicate a ratio >1, with dark red boxes as highly significant (p ≤0.05) and light red boxes as less significant (0.05<p<0.1). White boxes represent no change in expression.