Amiodarone Induces Overexpression of Similar to Versican b to Repress the EGFR/Gsk3b/Snail Signaling Axis during Cardiac Valve Formation of Zebrafish Embryos
Fig 5
The effect of Amiodarone on cell signaling pathways during cardiac valve formation.
(1) Amiodarone induces ectopic transcription of s-vcanb in nucleus. (2) S-vcanb protein was overexpressed in ECM. (3) S-vcanb/EGFR interaction inhibits EGFR signaling. (4) Inhibition of EGFR activity increases Gsk3b activity. (5) Activation of Gsk3b reduces the production of Snail protein. (6) Which increases the amount of E-cadherin protein, thus reducing EMT activity in endocardial cells.