Assessment of Interactions between Cisplatin and Two Histone Deacetylase Inhibitors in MCF7, T47D and MDA-MB-231 Human Breast Cancer Cell Lines – An Isobolographic Analysis
Fig 5
(A-F) Effects of CDDP and HDIs on cell cycle progression in breast cancer cells.
Effect of HDIs alone and in combination with CDDP on cell cycle in T47D, MCF7 and MDA-MB-231 cells. The cell lines were cultivated for 48 h with VPA or SAHA and CDDP (2.0 = 100% IC50) and analyzed by flow cytometry. The results are presented as mean + SD, n = 10 from five separate experiments.