Antagonistic Regulation of Parvalbumin Expression and Mitochondrial Calcium Handling Capacity in Renal Epithelial Cells
Fig 2
Relative mRNA expression levels of 7 selected genes determined by qRT-PCR based on results from Gene Chip Analysis (for more details, see S1 Table).
RNA levels of genes implicated in mitochondrial Ca2+ regulation: Efhd1, Micu1, Mcu, Mcur1 as well as other mitochondrial genes (Ucp2, COX1 and Atp5b) are upregulated in PV-deficient DCT cells (results are from n = 4 animals per genotype, mean ± sem. The upregulation is statistically significant for Micu1 and Atp5b (p<0.05, Mann-Whitney U test).