FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity
Fig 7
Proposed mechanism of FL3-induced cardioprotection from doxorubicin toxicity.
Doxorubicin induces the translocation of PHB1 and phosphorylated STAT3 in the nucleus of cardiomyocytes to induce apoptosis. On the opposite, FL3 induces the translocation of these signaling proteins into mitochondria to protect the cell against the adverse effects of doxorubicin.