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Pharmacological Mechanisms of Cortical Enhancement Induced by the Repetitive Pairing of Visual/Cholinergic Stimulation

Fig 3

Change in VEP amplitudes following pharmacological modulation during visual/cholinergic stimulation (VS/HDB).

The histograms represent the VEP difference of amplitude (Post-Pre training) for the different groups for the trained spatial frequency of 0.12 CPD (A) and 0.3 CPD (B). Note that the VEP amplitude enhancement following the visual/cholinergic training was blocked by MEC, AFDX, or PTX injection. (*; one-way ANOVA, post-hoc Dunnett, p < 0.05, compared to VS/HDB group, †; post-hoc Dunnett, p <0.05, compared to VS group). The error bars represent the average deviation. (Abbreviations; PZP: pirenzepine; MEC: mecamylamine; AFDX: AF-DX 116; MUS: muscimol and PTX: picrotoxin).

Fig 3

doi: https://doi.org/10.1371/journal.pone.0141663.g003