Esculentin-2CHa-Related Peptides Modulate Islet Cell Function and Improve Glucose Tolerance in Mice with Diet-Induced Obesity and Insulin Resistance
Fig 8
Effects of [L28K]esculentin-2CHa on islet morphology (A) and computed islet number (B), islet area (C), beta cell area (D) and alpha cell area (E) in lean and high-fat fed mice.
Mice were treated with twice-daily injections of saline or [L28K]esculentin-2CHa (75 nmol/kg body weight) for 28 days prior to excision of pancreatic tissue for immunohistological analysis. Values are mean ± SEM for 8 observations (~120 islets per group). *P < 0.05, **P < 0.01, ***P < 0.001 compared to lean control. ΔΔΔP < 0.001 compared to high fat control.