Esculentin-2CHa-Related Peptides Modulate Islet Cell Function and Improve Glucose Tolerance in Mice with Diet-Induced Obesity and Insulin Resistance
Fig 7
Effects of [L28K]esculentin-2CHa on plasma glucagon content (A), pancreatic glucagon content (B), plasma lipid profile (C), plasma concentrations of AST, ALT and ALP (D) and plasma level of creatinine (E) in lean and high-fat fed mice.
Mice were treated with twice-daily injections of saline or [L28K]esculentin-2CHa (75 nmol/kg body weight) for 28 days prior to measurement of biochemical parameters. Values are mean ± SEM with n = 8. *P < 0.05, **P < 0.01, ***P < 0.01 compared with lean control. ΔP < 0.05 compared with high-fat control.